NAD+

Nicotinamide Adenine Dinucleotide | Cellular Energy & Redox Biology Research Compound

■ For Research Use Only. Not for human or veterinary use. Not a drug, supplement, or food additive.

Intended exclusively for in-vitro and laboratory research by qualified investigators.

NAD+ – 500mg – A Central Coenzyme for Cellular Energy and Redox Biology Research

Category: Small Molecule Research Compounds / Metabolic Research / Cellular Bioenergetics

Disclaimer:

ATTENTION: PRIMALRESEARCHLABS.COM PRODUCTS ARE INTENDED FOR LABORATORY RESEARCH AND IN-VITRO STUDIES ONLY.

All information presented on this site is for educational and research purposes related to scientific investigation.

These products are strictly not for human or veterinary use, consumption, or diagnostic applications.

They are not pharmaceuticals, food additives, or dietary supplements.

By purchasing from PrimalResearchLabs.com, you acknowledge and affirm that you are a qualified researcher operating in a controlled laboratory environment.

You must adhere to all applicable local, state, and federal laws and regulations regarding the handling and use of research chemicals.

Handle all materials with appropriate personal protective equipment (PPE) and under laboratory safety protocols.

Biology

Nicotinamide adenine dinucleotide (NAD+) is a central coenzyme present in all living cells, playing a critical role in redox reactions, cellular energy production, and metabolic regulation.

It functions as an essential electron carrier in mitochondrial oxidative phosphorylation and glycolysis, enabling ATP generation and maintaining cellular energy balance.

NAD+ is of particular interest in metabolic and aging research due to its role as a substrate for sirtuins, poly(ADP-ribose) polymerases (PARPs), and CD38 enzymes, which are involved in DNA repair, gene expression regulation, and cellular stress responses.

Declining NAD+ levels have been associated with aging and metabolic dysfunction, making it a valuable compound for in-vitro and in-vivo experimental design across bioenergetics, longevity research, and cellular resilience studies.

This product is intended solely for in-vitro and preclinical research use and is not for human or veterinary consumption.

Key Research Applications of NAD+

Cellular Energy Production & Mitochondrial Function Research

NAD+ has demonstrated essential activity in cellular bioenergetics through:

Electron Transport Chain Function — Serves as a key cofactor in mitochondrial ATP production via oxidative phosphorylation.

Redox Balance Regulation — Maintains NAD+/NADH ratio critical for metabolic homeostasis.

Mitochondrial Efficiency — Supports cellular respiration and energy metabolism pathways.

Supporting Studies:

Verdin, E. — Science.

“NAD+ metabolism plays a central role in mitochondrial function and cellular energy homeostasis.”

■ PubMed – PMID: 26430185

Sirtuin Activation & Aging Research

NAD+ has been extensively studied in longevity and cellular aging pathways through:

Sirtuin Activation — Acts as a required cofactor for SIRT1–SIRT7 enzymes regulating gene expression and longevity pathways.

DNA Repair Mechanisms — Supports PARP-mediated DNA repair and genomic stability.

• Age-Related Decline Studies — Reduced NAD+ levels are associated with aging and metabolic dysfunction in research models.

Supporting Studies:

Imai, S. & Guarente, L. — Nature.

“NAD+ and sirtuins play a critical role in aging and metabolic regulation.”

■ PubMed – PMID: 21376309

Metabolic Regulation & Cellular Stress Response Research

NAD+ has been explored in metabolic and stress response studies through:

Glucose Metabolism Regulation — Influences glycolysis and insulin sensitivity pathways.

Oxidative Stress Resistance — Supports cellular defense against oxidative damage.

Inflammatory Pathway Modulation — Participates in regulation of immune and stress signaling pathways.

Supporting Studies:

Yoshino, J. et al. — Cell Metabolism.

“NAD+ intermediates enhance metabolic function and insulin sensitivity.”

■ PubMed – PMID: 23217256

Recommended Research Concentrations

Note: For laboratory research reference only. Not for human or veterinary use.

Research Model

Suggested Concentration

Administration

In-vitro metabolic assays

10–500 µM

Cell culture media

Mitochondrial studies

50–500 µM

Cell culture media

Animal models (rodents, IP/IV)

10–500 mg/kg

Injection

Why Choose Primal Research for Your NAD+ Research?

≥98% purity — critical for bioenergetics and enzymatic pathway studies

Independent third-party batch testing with COA available on request

High-stability formulation for controlled experimental use

Available in 500mg quantity — supports advanced metabolic and longevity research protocols

Storage & Handling

Store at -20°C, desiccated and protected from light

Soluble in sterile water or bacteriostatic water; for optimal stability, sterile water or buffered solutions are recommended

Prepare fresh solutions prior to each experiment

Avoid repeated freeze-thaw cycles

Technical Specifications

Compound: Nicotinamide Adenine Dinucleotide (NAD+)

Molecular Weight: ~663.4 g/mol

Molecular Formula: C21H27N7O14P2

Purity: ≥98%

Form: Lyophilized powder — available in 500mg

Storage: -20°C, desiccated, light-protected

Solubility: Soluble in sterile water or bacteriostatic water

COA: Available per batch on request

Advance Your Cellular Energy & Longevity Research

Order your NAD+ 500mg today to support advanced research in mitochondrial function, metabolic regulation, and aging biology.

Primal Research products are sold strictly for in-vitro and laboratory research use only. Not for human or veterinary consumption.

Not intended to diagnose, treat, cure, or prevent any disease or condition.

Purchasers are responsible for compliance with all applicable local, state, and federal regulations.