Epithalon

Epithalon — 10mg | 50mg

Telomerase-Activating Tetrapeptide | Longevity & Cellular Aging Research Compound

■ For Research Use Only. Not for human or veterinary use. Not a drug, supplement, or food additive.

Intended exclusively for in-vitro and laboratory research by qualified investigators.

Epithalon – 10mg / 50mg – A Telomerase-Activating Peptide for Longevity and Cellular Aging Research

Category: Peptide Research Compounds / Longevity Research / Telomere Biology & Cellular Aging

Disclaimer:

ATTENTION: PRIMALRESEARCHLABS.COM PRODUCTS ARE INTENDED FOR LABORATORY RESEARCH AND IN-VITRO STUDIES ONLY.

All information presented on this site is for educational and research purposes related to scientific investigation.

These products are strictly not for human or veterinary use, consumption, or diagnostic applications.

They are not pharmaceuticals, food additives, or dietary supplements.

By purchasing from PrimalResearchLabs.com, you acknowledge and affirm that you are a qualified researcher operating in a controlled laboratory environment.

You must adhere to all applicable local, state, and federal laws and regulations regarding the handling and use of research chemicals.

Handle all materials with appropriate personal protective equipment (PPE) and under laboratory safety protocols.

Biology

Epithalon (Ala-Glu-Asp-Gly) is a synthetic tetrapeptide analog of the naturally occurring pineal peptide Epithalamin, designed to investigate mechanisms of cellular aging, telomere dynamics, and circadian regulation.

It has been extensively studied in preclinical and clinical research models for its ability to activate telomerase, elongate telomeres, and modulate gene expression associated with cellular lifespan and genomic stability.

Epithalon is of particular interest in longevity research due to its reported influence on chromosomal integrity, oxidative stress regulation, and pineal gland signaling pathways.

Its small molecular structure and stability make it a versatile tool for in-vitro and in-vivo experimental design across aging, regenerative biology, and endocrine signaling studies.

This product is intended solely for in-vitro and preclinical research use and is not for human or veterinary consumption.

Key Research Applications of Epithalon

1. Telomere Biology & Cellular Senescence Research

Epithalon has demonstrated significant activity in telomere-related studies through:

Telomerase Activation — Induces telomerase expression in human somatic cell cultures, leading to elongation of telomeres and delayed replicative senescence (Khavinson et al.).

Chromosomal Stability — Associated with reduced chromosomal aberrations and enhanced DNA integrity in aging cell populations.

Extended Cellular Lifespan — Increased proliferative capacity observed in fibroblast cultures, supporting its role in cellular longevity research models.

Supporting Studies:

Khavinson, V. et al. — Bulletin of Experimental Biology and Medicine.

“Epithalon induced telomerase activity and telomere elongation in human somatic cells, contributing to extended cellular lifespan in vitro.”

2. Pineal Gland Function & Circadian Rhythm Research

Epithalon has been investigated for its role in neuroendocrine regulation through:

Melatonin Secretion Modulation — Stimulates pineal gland activity, increasing melatonin production in aging animal models.

Circadian Rhythm Regulation — Restores disrupted circadian cycles, making it a valuable tool in chronobiology research.

Neuroendocrine Axis Support — Influences hypothalamic-pituitary signaling pathways linked to aging and hormonal balance.

Supporting Studies:

Anisimov, V.N. et al. — Neuroendocrinology Letters.

“Epithalon administration restored melatonin production and improved circadian rhythm regulation in aged animal models.”

3. Oxidative Stress & Longevity Pathway Research

Epithalon has been explored in oxidative stress and aging-related pathways through:

Antioxidant Enzyme Activation — Upregulates endogenous antioxidant systems, including superoxide dismutase (SOD) and catalase.

Reduced Lipid Peroxidation — Demonstrates decreased markers of oxidative damage in cellular and animal models.

Longevity-Associated Effects — Long-term studies in animal models have reported increased lifespan and improved physiological markers of aging.

Supporting Studies:

Anisimov, V.N. et al. — Annals of the New York Academy of Sciences.

“Long-term Epithalon administration was associated with increased lifespan and reduced incidence of age-related pathologies in animal models.”

Recommended Research Concentrations

Note: For laboratory research reference only. Not for human or veterinary use.

Research Model
Suggested Concentration
Administration

In-vitro cell culture studies
1–100 µM
Cell culture media

Telomerase activity assays
10–50 µM
Assay buffer

Animal models (rodents, SC/IP)
0.1–1 mg/kg
Injection

Why Choose Primal Research for Your Epithalon Research?

≥98% HPLC-verified purity — critical for telomerase and gene expression studies

Independent third-party batch testing with COA available on request

Lyophilized powder for maximum stability and long-term storage

Available in 10mg and 50mg quantities — supports both small-scale and extended research protocols

Storage & Handling

Store at -20°C, desiccated and protected from light

Soluble in sterile water or appropriate aqueous buffer

Prepare fresh solutions prior to each experiment

Avoid repeated freeze-thaw cycles

Technical Specifications

Compound: Epithalon (Ala-Glu-Asp-Gly)

Molecular Weight: 390.35 g/mol

Molecular Formula: C14H22N4O9

Purity: ≥98% (HPLC Verified)

Form: Lyophilized powder — available in 10mg and 50mg

Storage: -20°C, desiccated, light-protected

Solubility: Soluble in sterile water or aqueous buffer

COA: Available per batch on request

Advance Your Longevity Research

Order your Epithalon (10mg or 50mg) today to support advanced research in telomere biology, cellular aging, and longevity science.

Final Disclaimer:

Primal Research products are sold strictly for in-vitro and laboratory research use only.

Not for human or veterinary consumption.

Not intended to diagnose, treat, cure, or prevent any disease or condition.

Purchasers are responsible for compliance with all applicable local, state, and federal regulations.