C-Amylin (Cagrilintide) – 5mg 
A Long-Acting Amylin Analog for Metabolic and Satiety Research
An Amylin / Calcitonin Receptor Agonist for Energy-Balance and Obesity Studies

Category: Peptide Research Compounds / Metabolic Research / Amylin Biology

For Research Use Only. Not for human or veterinary use. Not a drug, supplement, or food additive. Intended exclusively for in-vitro and laboratory research by qualified investigators.

DISCLAIMER
ATTENTION: PRIMALRESEARCHLABS.COM products are intended for laboratory research and in-vitro studies only. All information presented is for educational and research purposes related to scientific investigation. These products are strictly not for human or veterinary use, consumption, or diagnostic applications. They are not pharmaceuticals, food additives, or dietary supplements. By purchasing from PRIMALRESEARCHLABS.COM, you acknowledge that you are a qualified researcher operating in a controlled laboratory environment. Adhere to all applicable local, state, and federal laws and regulations regarding handling and use of research chemicals. Use appropriate personal protective equipment (PPE) and follow laboratory safety protocols.

BIOLOGY
C-Amylin (cagrilintide) is a long-acting synthetic analog of amylin, a pancreatic hormone co-secreted with insulin from beta cells that contributes to the control of satiety and energy homeostasis. Cagrilintide acts as a dual agonist at amylin and calcitonin receptors, with activity in the area postrema and other brain regions involved in appetite regulation.

Cagrilintide has been investigated in preclinical and clinical research models examining body-weight regulation, food intake, and energy balance, both alone and in combination with GLP-1 receptor agonists. Its once-weekly pharmacokinetic profile and receptor activity make it a valuable tool for in-vitro and in-vivo experimental design across obesity research, metabolic studies, and amylin-receptor signaling.

This product is intended solely for in-vitro and preclinical research use and is not for human or veterinary consumption.

KEY RESEARCH APPLICATIONS OF C-AMYLIN

1. Amylin & Calcitonin Receptor Signaling
C-Amylin demonstrates significant activity in metabolic studies through:
• Receptor Agonism: Dual agonist activity at amylin and calcitonin receptors.
• Area Postrema Signaling: Acts on brain regions governing satiety.
• Energy Homeostasis: Studied for modulation of energy-balance pathways.
Supporting Studies:
Lau, D.C.W. et al. — The Lancet. “Once-weekly cagrilintide for weight management in people with overweight and obesity: a multicentre, randomised, double-blind, placebo-controlled and active-controlled, dose-finding phase 2 trial.” PubMed – PMID: 34798060

2. Body-Weight & Appetite Regulation
Investigated in obesity and metabolic research models through:
• Food Intake: Studied for reduction of caloric intake via satiety pathways.
• Weight Reduction: Demonstrated dose-dependent body-weight reduction in trials.
• Energy Balance: Examined for influence on metabolic efficiency.
Supporting Studies:
Enebo, L.B. et al. — The Lancet. “Safety, tolerability, pharmacokinetics, and pharmacodynamics of concomitant administration of multiple doses of cagrilintide with semaglutide.” PubMed – PMID: 33894838

3. Combination Metabolic Research
Explored in broader metabolic research through:
• GLP-1 Combination: Studied alongside GLP-1 receptor agonists (e.g., semaglutide).
• Additive Effects: Examined for complementary effects on appetite and weight.
• Metabolic Modeling: Applied across obesity and incretin research.
Supporting Studies:
Frias, J.P. et al. — The Lancet. “Efficacy and safety of co-administered once-weekly cagrilintide 2.4 mg with once-weekly semaglutide 2.4 mg in type 2 diabetes: a phase 2 trial.” PubMed – PMID: 37364590

RECOMMENDED RESEARCH CONCENTRATIONS
For laboratory research reference only. Not for human or veterinary use.
• In-vitro receptor assays — 1-100 nM — Assay buffer
• Metabolic pathway studies — 1-50 nM — Cell culture media
• Animal models (rodents, SC) — Per protocol — Injection

WHY CHOOSE PRIMAL RESEARCH FOR YOUR C-AMYLIN STUDIES?
• ≥98% HPLC-verified purity — critical for amylin receptor binding studies
• Independent third-party batch testing with COA available on request
• Lyophilized powder for maximum stability and long-term storage
• Available in 5mg and 10mg quantities — supports scalable metabolic protocols

STORAGE & HANDLING
• Store at -20°C, desiccated and protected from light
• Soluble in sterile water or bacteriostatic water
• Prepare fresh solutions prior to each experiment
• Avoid repeated freeze-thaw cycles

TECHNICAL SPECIFICATIONS
Compound: C-Amylin (Cagrilintide)
Molecular Weight: ~3731 g/mol
Purity: ≥98% (HPLC Verified)
Form: Lyophilized powder — 5mg and 10mg
Storage: -20°C, desiccated, light-protected
Solubility: Soluble in sterile or bacteriostatic water
COA: Available per batch on request

ADVANCE YOUR RESEARCH
Order your C-Amylin today to support advanced research in amylin-receptor signaling, appetite regulation, and metabolic disease modeling.

Primal Research products are sold strictly for in-vitro and laboratory research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease or condition. Purchasers are responsible for compliance with all applicable local, state, and federal regulations.