MOTS-c

Mitochondrial-Derived Peptide | Metabolic & Cellular Energy Research Compound

■ For Research Use Only. Not for human or veterinary use. Not a drug, supplement, or food additive.

Intended exclusively for in-vitro and laboratory research by qualified investigators.

MOTS-c – 10mg / 20mg / 40mg – A Mitochondrial-Derived Peptide for Metabolic Regulation and Cellular Energy Research

Category: Peptide Research Compounds / Metabolic Research / Mitochondrial Biology

Disclaimer:

ATTENTION: PRIMALRESEARCHLABS.COM PRODUCTS ARE INTENDED FOR LABORATORY RESEARCH AND IN-VITRO STUDIES ONLY.

All information presented on this site is for educational and research purposes related to scientific investigation.

These products are strictly not for human or veterinary use, consumption, or diagnostic applications.

They are not pharmaceuticals, food additives, or dietary supplements.

By purchasing from PrimalResearchLabs.com, you acknowledge and affirm that you are a qualified researcher operating in a controlled laboratory environment.

You must adhere to all applicable local, state, and federal laws and regulations regarding the handling and use of research chemicals.

Handle all materials with appropriate personal protective equipment (PPE) and under laboratory safety protocols.

Biology

MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) is a mitochondrial-derived peptide encoded within the mitochondrial genome, representing a novel class of signaling molecules that link mitochondrial function to nuclear gene expression.

It has been extensively studied in preclinical models for its role in metabolic homeostasis, insulin sensitivity, and cellular stress response pathways.

MOTS-c is of particular interest in metabolic research due to its ability to translocate to the nucleus under metabolic stress conditions and regulate genes involved in energy metabolism, glucose utilization, and oxidative stress resistance.

Its unique role as a mitochondria-to-nucleus signaling peptide makes it a valuable tool for in-vitro and in-vivo experimental design across metabolic disease models, mitochondrial biology, and aging research.

This product is intended solely for in-vitro and preclinical research use and is not for human or veterinary consumption.

Key Research Applications of MOTS-c

Metabolic Regulation & Insulin Sensitivity Research

MOTS-c has demonstrated significant activity in metabolic studies through:

AMPK Activation — Enhances glucose uptake and fatty acid oxidation via activation of AMP-activated protein kinase pathways.

Insulin Sensitivity Improvement — Improves insulin signaling and glucose homeostasis in experimental models.

Obesity Model Research — Reduces weight gain and improves metabolic markers in diet-induced obesity models.

Supporting Studies:

Lee, C. et al. — Cell Metabolism.

“The mitochondrial-derived peptide MOTS-c regulates metabolic homeostasis and insulin sensitivity.”

■ PubMed – PMID: 25651178

Mitochondrial Function & Cellular Stress Response Research

MOTS-c has been investigated in mitochondrial biology through:

Nuclear Translocation — Moves to the nucleus under metabolic stress to regulate adaptive gene expression.

Oxidative Stress Resistance — Enhances cellular defense against oxidative damage.

Energy Homeostasis Regulation — Supports mitochondrial function and ATP production pathways.

Supporting Studies:

Kim, K.H. et al. — Nature Communications.

“MOTS-c translocates to the nucleus to regulate stress-responsive gene expression.”

■ PubMed – PMID: 28128265

Aging & Longevity Research

MOTS-c has been explored in aging-related studies through:

Longevity Pathway Activation — Associated with metabolic regulation pathways linked to lifespan extension.

Exercise-Mimetic Effects — Demonstrates exercise-like metabolic benefits in experimental models.

Cellular Adaptation Mechanisms — Enhances resilience to metabolic stress and age-related decline.

Supporting Studies:

Reynolds, J.C. et al. — Nature Communications.

“MOTS-c promotes metabolic homeostasis and physical capacity in aging models.”

■ PubMed – PMID: 32210205

Recommended Research Concentrations

Note: For laboratory research reference only. Not for human or veterinary use.

Research Model

Suggested Concentration

Administration

In-vitro metabolic assays

1–10 µM

Cell culture media

Mitochondrial function studies

1–20 µM

Cell culture media

Animal models (rodents, SC/IP)

0.1–1 mg/kg

Injection

Why Choose Primal Research for Your MOTS-c Research?

≥98% HPLC-verified purity — critical for mitochondrial signaling and metabolic pathway studies

Independent third-party batch testing with COA available on request

Lyophilized powder for maximum stability and long-term storage

Available in 10mg, 20mg, and 40mg quantities — supports both small-scale and extended research protocols

Storage & Handling

Store at -20°C, desiccated and protected from light

Soluble in sterile water or bacteriostatic water

Prepare fresh solutions prior to each experiment

Avoid repeated freeze-thaw cycles

Technical Specifications

Compound: MOTS-c

Molecular Weight: ~2174 g/mol

Purity: ≥98% (HPLC Verified)

Form: Lyophilized powder — available in 10mg, 20mg, and 40mg

Storage: -20°C, desiccated, light-protected

Solubility: Soluble in sterile water or bacteriostatic water

COA: Available per batch on request

Advance Your Metabolic & Mitochondrial Research

Order your MOTS-c today to support advanced research in metabolic regulation, mitochondrial biology, and cellular energy systems.

Primal Research products are sold strictly for in-vitro and laboratory research use only.

Not for human or veterinary consumption.

Not intended to diagnose, treat, cure, or prevent any disease or condition.

Purchasers are responsible for compliance with all applicable local, state, and federal regulations.