KPV

KPV – 5mg / 10mg
The C-Terminal Tripeptide of alpha-MSH for Inflammation Research
A Lys-Pro-Val Melanocortin Tripeptide for Anti-Inflammatory Pathway Studies

Category: Peptide Research Compounds / Inflammation / Melanocortin Biology

For Research Use Only. Not for human or veterinary use. Not a drug, supplement, or food additive. Intended exclusively for in-vitro and laboratory research by qualified investigators.

DISCLAIMER
ATTENTION: PRIMALRESEARCHLABS.COM products are intended for laboratory research and in-vitro studies only. All information presented is for educational and research purposes related to scientific investigation. These products are strictly not for human or veterinary use, consumption, or diagnostic applications. They are not pharmaceuticals, food additives, or dietary supplements. By purchasing from PRIMALRESEARCHLABS.COM, you acknowledge that you are a qualified researcher operating in a controlled laboratory environment. Adhere to all applicable local, state, and federal laws and regulations regarding handling and use of research chemicals. Use appropriate personal protective equipment (PPE) and follow laboratory safety protocols.

BIOLOGY
KPV is a tripeptide (Lys-Pro-Val) corresponding to the C-terminal sequence (residues 11-13) of alpha-melanocyte-stimulating hormone (alpha-MSH). Despite its small size, KPV retains notable anti-inflammatory activity and is studied for its ability to modulate inflammatory signaling without inducing the pigmentary effects associated with full-length alpha-MSH.

KPV has been investigated in preclinical research models examining intestinal inflammation, NF-kappaB and MAP kinase signaling, and pro-inflammatory cytokine expression. Research indicates KPV can be transported into cells via the PepT1 di/tripeptide transporter, where it modulates intracellular inflammatory pathways. These properties make it a valuable tool for in-vitro and in-vivo inflammation research.

This product is intended solely for in-vitro and preclinical research use and is not for human or veterinary consumption.

KEY RESEARCH APPLICATIONS OF KPV

1. Anti-Inflammatory Signaling
KPV demonstrates significant activity in inflammation studies through:
• NF-kappaB Modulation: Inhibits activation of NF-kappaB inflammatory signaling.
• MAP Kinase Pathways: Studied for downregulation of MAPK inflammatory cascades.
• Cytokine Reduction: Reduces secretion of pro-inflammatory cytokines in cell models.
Supporting Studies:
Dalmasso, G. et al. — Gastroenterology. “PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation.” PubMed – PMID: 18061177

2. Intestinal & Mucosal Inflammation
Investigated in gastrointestinal inflammation models through:
• Colitis Models: Examined in DSS- and TNBS-induced experimental colitis.
• Epithelial Cell Response: Studied in intestinal epithelial cell cultures.
• PepT1 Transport: Uptake mediated by the PepT1 di/tripeptide transporter.
Supporting Studies:
Kannengiesser, K. et al. — Inflammatory Bowel Diseases. “Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease.” PubMed – PMID: 18092346

3. Melanocortin Pathway Research
Explored in broader inflammation research through:
• Leukocyte Migration: Studied for antimigratory effects in peritonitis models.
• Receptor-Independent Action: Activity studied independent of melanocortin receptors.
• Comparative Peptide Studies: Reference fragment within alpha-MSH research.
Supporting Studies:
Getting, S.J. et al. — British Journal of Pharmacology. “Dissection of the anti-inflammatory effect of the core and C-terminal (KPV) alpha-melanocyte-stimulating hormone peptides.” PubMed – PMID: 12750433

RECOMMENDED RESEARCH CONCENTRATIONS
For laboratory research reference only. Not for human or veterinary use.
• In-vitro inflammation assays — 1-100 nM — Assay buffer
• Epithelial cell culture — 1-100 µM — Cell culture media
• Animal models (rodents) — Per protocol — Oral / SC

WHY CHOOSE PRIMAL RESEARCH FOR YOUR KPV STUDIES?
• ≥98% HPLC-verified purity — critical for inflammation signaling studies
• Independent third-party batch testing with COA available on request
• Lyophilized powder for maximum stability and long-term storage
• Available in 5mg and 10mg quantities — supports scalable inflammation protocols

STORAGE & HANDLING
• Store at -20°C, desiccated and protected from light
• Soluble in sterile water or bacteriostatic water
• Prepare fresh solutions prior to each experiment
• Avoid repeated freeze-thaw cycles

TECHNICAL SPECIFICATIONS
Compound: KPV (Lys-Pro-Val)
Molecular Weight: ~342 g/mol
Purity: ≥98% (HPLC Verified)
Form: Lyophilized powder — 5mg and 10mg
Storage: -20°C, desiccated, light-protected
Solubility: Soluble in sterile or bacteriostatic water
COA: Available per batch on request

ADVANCE YOUR RESEARCH
Order your KPV today to support advanced research in melanocortin biology, anti-inflammatory signaling, and intestinal inflammation modeling.

Primal Research products are sold strictly for in-vitro and laboratory research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease or condition. Purchasers are responsible for compliance with all applicable local, state, and federal regulations.