IGF1-LR3

IGF-1 LR3 – 1mg
A Long-Acting Analog of Insulin-Like Growth Factor 1 for Cellular Research
An 83-Amino-Acid IGF-1 Analog for Growth, Proliferation, and Signaling Studies

Category: Peptide Research Compounds / Growth Factor Biology / Cell Proliferation

For Research Use Only. Not for human or veterinary use. Not a drug, supplement, or food additive. Intended exclusively for in-vitro and laboratory research by qualified investigators.

DISCLAIMER
ATTENTION: PRIMALRESEARCHLABS.COM products are intended for laboratory research and in-vitro studies only. All information presented is for educational and research purposes related to scientific investigation. These products are strictly not for human or veterinary use, consumption, or diagnostic applications. They are not pharmaceuticals, food additives, or dietary supplements. By purchasing from PRIMALRESEARCHLABS.COM, you acknowledge that you are a qualified researcher operating in a controlled laboratory environment. Adhere to all applicable local, state, and federal laws and regulations regarding handling and use of research chemicals. Use appropriate personal protective equipment (PPE) and follow laboratory safety protocols.

BIOLOGY
IGF-1 LR3 (Long R3 IGF-1) is an 83-amino-acid synthetic analog of human insulin-like growth factor 1. It differs from native IGF-1 by an arginine substitution at position 3 and a 13-amino-acid N-terminal extension. These modifications reduce its affinity for IGF-binding proteins and increase its metabolic stability, giving it a substantially longer half-life and greater potency than native IGF-1.

IGF-1 LR3 acts as an agonist of the IGF-1 receptor, activating PI3K/Akt and MAPK/ERK signaling pathways that drive protein synthesis and cell proliferation. It has been used extensively in preclinical and cell-culture research as a potent supplement for serum-free culture systems and as a tool for studying growth-factor signaling, making it valuable for in-vitro and in-vivo experimental design across cell biology and metabolism research.

This product is intended solely for in-vitro and preclinical research use and is not for human or veterinary consumption.

KEY RESEARCH APPLICATIONS OF IGF-1 LR3

1. IGF-1 Receptor Signaling & Cell Proliferation
IGF-1 LR3 demonstrates significant activity in cell biology studies through:
• Receptor Activation: Agonist activity at the IGF-1 receptor (IGF-1R).
• PI3K/Akt Signaling: Activates pathways driving protein synthesis.
• MAPK/ERK Signaling: Stimulates cell proliferation cascades.
Supporting Studies:
Tomas, F.M. et al. — Journal of Endocrinology. “Long R3 IGF-I infusion stimulates organ growth but reduces plasma IGF-I, IGF-II and IGF binding protein concentrations in the guinea pig.” PubMed – PMID: 7561636

2. Skeletal Muscle & Myogenesis Research
Investigated in muscle and growth research models through:
• Satellite Cell Activity: IGF-1 signaling studied in muscle satellite cells.
• Myogenic Differentiation: Examined for effects on myoblast proliferation.
• Muscle Mass Pathways: Applied in studies of skeletal muscle physiology.
Supporting Studies:
Yoshida, T. & Delafontaine, P. — Cells. “Mechanisms of IGF-1-mediated regulation of skeletal muscle hypertrophy and atrophy.” PubMed – PMID: 32825676

3. Cell-Culture & Metabolic Research
Explored in broader cell biology research through:
• Serum-Free Culture: Used as a potent growth supplement in culture systems.
• Reduced IGFBP Binding: Low binding-protein affinity increases free-ligand activity.
• Glucose & Metabolism: Studied in adipocyte and glucose-uptake models.
Supporting Studies:
Dunaiski, V. & Belford, D.A. — Journal of Endocrinology. “Long [R3] insulin-like growth factor-I reduces growth, plasma growth hormone and IGF binding protein-3 in pigs.” PubMed – PMID: 9488001

RECOMMENDED RESEARCH CONCENTRATIONS
For laboratory research reference only. Not for human or veterinary use.
• In-vitro cell culture — 1-100 ng/mL — Cell culture media
• Serum-free supplementation — 10-100 ng/mL — Culture media
• Animal models (rodents, SC) — Per protocol — Injection

WHY CHOOSE PRIMAL RESEARCH FOR YOUR IGF-1 LR3 STUDIES?
• ≥98% HPLC-verified purity — critical for receptor signaling studies
• Independent third-party batch testing with COA available on request
• Lyophilized powder for maximum stability and long-term storage
• Available in 0.1mg and 1mg quantities — supports scalable cell-culture protocols

STORAGE & HANDLING
• Store at -20°C, desiccated and protected from light
• Soluble in sterile water or bacteriostatic water
• Prepare fresh solutions prior to each experiment
• Avoid repeated freeze-thaw cycles

TECHNICAL SPECIFICATIONS
Compound: IGF-1 LR3 (Long R3 IGF-1)
Molecular Weight: ~9111 g/mol (83 aa)
Purity: ≥98% (HPLC Verified)
Form: Lyophilized powder — 0.1mg and 1mg
Storage: -20°C, desiccated, light-protected
Solubility: Soluble in dilute acetic acid or sterile water per protocol
COA: Available per batch on request

ADVANCE YOUR RESEARCH
Order your IGF-1 LR3 today to support advanced research in growth-factor signaling, cell proliferation, and skeletal muscle biology.

Primal Research products are sold strictly for in-vitro and laboratory research use only. Not for human or veterinary consumption. Not intended to diagnose, treat, cure, or prevent any disease or condition. Purchasers are responsible for compliance with all applicable local, state, and federal regulations.