GHK-CU

Copper-Binding Tripeptide Complex | Tissue Repair & Regenerative Biology Research Compound

■ For Research Use Only. Not for human or veterinary use. Not a drug, supplement, or food additive.

Intended exclusively for in-vitro and laboratory research by qualified investigators.

GHK-Cu – 50mg – A Copper-Binding Tripeptide for Tissue Repair and Regenerative Research

Category: Peptide Research Compounds / Regenerative Biology / Tissue Repair & Skin Biology

Disclaimer:

ATTENTION: PRIMALRESEARCHLABS.COM PRODUCTS ARE INTENDED FOR LABORATORY RESEARCH AND IN-VITRO STUDIES ONLY.

All information presented on this site is for educational and research purposes related to scientific investigation.

These products are strictly not for human or veterinary use, consumption, or diagnostic applications.

They are not pharmaceuticals, food additives, or dietary supplements.

By purchasing from PrimalResearchLabs.com, you acknowledge and affirm that you are a qualified researcher operating in a controlled laboratory environment.

You must adhere to all applicable local, state, and federal laws and regulations regarding the handling and use of research chemicals.

Handle all materials with appropriate personal protective equipment (PPE) and under laboratory safety protocols.

Biology

GHK-Cu (glycyl-L-histidyl-L-lysine copper complex) is a naturally occurring copper-binding tripeptide originally identified in human plasma and later detected in saliva and urine.

It has been extensively studied in preclinical research for its role in tissue remodeling, wound repair, extracellular matrix regulation, and gene expression modulation.

GHK-Cu is of particular interest in regenerative biology due to its reported ability to stimulate collagen synthesis, enhance fibroblast activity, regulate metalloproteinase expression, and promote angiogenesis in experimental models.

Its broad biological activity and stability make it a versatile tool for in-vitro and in-vivo experimental design across skin biology, connective tissue research, and wound healing studies.

This product is intended solely for in-vitro and preclinical research use and is not for human or veterinary consumption.

Key Research Applications of GHK-Cu

Tissue Repair & Extracellular Matrix Remodeling Research

GHK-Cu has demonstrated significant activity in tissue repair studies through:

Collagen Synthesis Stimulation — Increases production of collagen types I and III and glycosaminoglycans in fibroblast culture systems.

Fibroblast Activation — Enhances fibroblast proliferation and migration, supporting wound healing and dermal regeneration models.

Matrix Remodeling Regulation — Modulates matrix metalloproteinases (MMPs) and their inhibitors, contributing to controlled extracellular matrix turnover.

Supporting Studies:

Maquart, F.X. et al. — Biochimica et Biophysica Acta.

“Copper-peptide complexes stimulate accumulation of extracellular matrix components in cultured fibroblasts.”

■ PubMed – PMID: 3703959

Wound Healing & Angiogenesis Research

GHK-Cu has been investigated for its role in tissue regeneration and vascular biology through:

Accelerated Wound Healing — Associated with faster wound contraction and improved tissue organization in preclinical models.

Angiogenesis Promotion — Stimulates vascular endothelial growth factor (VEGF) expression and capillary formation.

Tissue Regeneration Support — Enhances granulation tissue formation and structural repair.

Supporting Studies:

Pickart, L. et al. — Journal of Biomaterials Science.

“GHK-Cu promotes wound healing and angiogenesis through modulation of cellular signaling pathways.”

■ PubMed – PMID: 16412543

Anti-Inflammatory & Oxidative Stress Research

GHK-Cu has been explored in oxidative stress and inflammation studies through:

Cytokine Modulation — Reduces pro-inflammatory cytokines and supports balanced immune response signaling.

Antioxidant Activity — Enhances endogenous antioxidant enzyme systems, including superoxide dismutase activity.

Cellular Protection — Demonstrates protective effects against oxidative damage in stressed cellular environments.

Supporting Studies:

Pickart, L. & Margolina, A. — International Journal of Molecular Sciences.

“GHK-Cu modulates gene expression associated with antioxidant defense, inflammation control, and tissue repair.”

■ PubMed – PMID: 29772703

Recommended Research Concentrations

Note: For laboratory research reference only. Not for human or veterinary use.

Research Model

Suggested Concentration

Administration

In-vitro fibroblast studies

1–10 µM

Cell culture media

Wound healing assays

1–20 µM

Cell culture media

Animal models (rodents, topical/injection)

0.1–1 mg/kg

Topical or injection

Why Choose Primal Research for Your GHK-Cu Research?

≥98% HPLC-verified purity — critical for gene expression and regenerative pathway studies

Independent third-party batch testing with COA available on request

Lyophilized powder for maximum stability and long-term storage

Available in 50mg quantity — supports extended multi-phase research protocols

Storage & Handling

Store at -20°C, desiccated and protected from light

Soluble in sterile water or bacteriostatic water

Prepare fresh solutions prior to each experiment

Avoid repeated freeze-thaw cycles

Technical Specifications

Compound: GHK-Cu (glycyl-L-histidyl-L-lysine copper complex)

Molecular Weight: ~403.38 g/mol

Molecular Formula: C14H24CuN6O4

Purity: ≥98% (HPLC Verified)

Form: Lyophilized powder — available in 50mg

Storage: -20°C, desiccated, light-protected

Solubility: Soluble in sterile water or bacteriostatic water

COA: Available per batch on request

Advance Your Regenerative Biology Research

Order your GHK-Cu 50mg today to support advanced research in tissue repair, wound healing, and skin regeneration science.

Final Disclaimer:

Primal Research products are sold strictly for in-vitro and laboratory research use only.

Not for human or veterinary consumption.

Not intended to diagnose, treat, cure, or prevent any disease or condition.

Purchasers are responsible for compliance with all applicable local, state, and federal regulations.